A Bibliometric Analysis of Research Trends, Themes and Collaborations in Skin Whitening Studies Using Scopus Data
DOI:
https://doi.org/10.11594/Keywords:
Depigmentation, whitening, lightening, skin whitening, bleaching, fairnessAbstract
Skin whitening has become a significant area of research in cosmetics science and dermatology due to the increasing global demand for products that reduce skin pigmentation and improve skin appearance. This study presents a bibliometric analysis of skin whitening research published between 2021 and 2024 using 175 documents retrieved from the Scopus database. Bibliometric analyses and network visualization were performed using Biblioshiny in R, while Microsoft Excel for data cleaning. The study examined publication trends, leading countries and institutions, citation performance, collaboration networks, and thematic evolution of research in the field. The findings revealed that China, South Korea, and the United States were the most productive contributors, while the Journal of Cosmetics Dermatology and the International Journal of Molecular Sciences emerged as the leading publication sources. Thematic analysis showed that research has progressively shifted from traditional depigmentation agents and clinical dermatology toward molecular mechanisms, skin pigmentation pathways, therapeutic innovations, and advanced cosmetic formulations. Increasing International collaboration and interdisciplinary research further indicate the growing scientific interest in skin whitening studies. These findings provide a comprehensive overview of the current knowledge structure and emerging research directions in skin whitening research, offering valuable insight for researchers, dermatologists, cosmetic scientists, and policymakers in guiding future investigations, product development and evidence-based public health and regulatory initiatives.
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Akinwumi, B. C., Bordun, K. A. M., & Anderson, H. D. (2018). Biological activities of stilbenoids. International Journal of Molecular Sciences, 19(3). https://doi.org/10.3390/ijms19030792
Bharti, N., Banerjee, R., Achalare, A., et al. (2024). Estimation of genetic variation in vitiligo-associated genes: Population genomics perspective. BMC Genomic Data, 25(1). https://doi.org/10.1186/s12863-024-01254-6
Boniface, K., Séneschal, J., Picardo, M., & Taïeb, A. (2018). Vitiligo: Focus on clinical aspects, immunopathogenesis, and therapy. Clinical Reviews in Allergy and Immunology, 54(1), 52–67. https://doi.org/10.1007/s12016-017-8622-7
Boo, Y. C. (2019). p-Coumaric acid as an active ingredient in cosmetics: A review focusing on its antimelanogenic effects. Antioxidants, 8(8). https://doi.org/10.3390/antiox8080275
Choi, J. H., Kwak, T., Shin, H., et al. (2024). Hydrolyzed cow colostrum extract (BCFM) inhibits alpha-MSH-induced melanogenesis in B16F1 cells via regulation of the MC1R-cAMP signaling pathway. Cytotechnology, 76(6), 847–858. https://doi.org/10.1007/s10616-024-00657-8
Cotts, L., Costa, G., Gabriel, S. I., et al. (2024). Unveiling the colors of mustelids: A historical review on the emergence of chromatic disorders and their ecological effects. Animals, 14(23). https://doi.org/10.3390/ani14233354
Dai, D., Sari, E. M., Si, J., et al. (2024). Genomic analysis reveals the association of KIT and MITF variants with the white spotting in swamp buffaloes. BMC Genomics, 25(1). https://doi.org/10.1186/s12864-024-10634-2
Darkazali, R., & Hamadah, O. (2024). Advantages of super pulsed CO₂ laser in gingival depigmentation: A report of two cases and review of the literature. Lasers in Dental Science, 8(1). https://doi.org/10.1007/s41547-024-00271-z
Dymek, M., Warszycki, D., Podlewska, S., et al. (2024). Novel tripeptides as tyrosinase inhibitors: In silico and in vitro approaches. International Journal of Molecular Sciences, 25(24). https://doi.org/10.3390/ijms252413509
Falade, A. O., Nwodo, U. U., Iweriebor, B. C., Green, E., Mabinya, L. V., & Okoh, A. I. (2017). Lignin peroxidase functionalities and prospective applications. MicrobiologyOpen, 6(1). https://doi.org/10.1002/mbo3.394
Feily, A., Hosseinpour, M., Samipour, L., et al. (2024). Silymarin in combination with hair follicle transplantation as a potential treatment for refractory vitiligo: A double-blind randomized controlled trial. Journal of Cosmetic Dermatology, 23(12), 4167–4172. https://doi.org/10.1111/jocd.16525
Gohary, Y. M., Abdelhady, E. G., Sayed, A. N., et al. (2024). Clinical study of Wnt inhibitory factor-1 expression and its association with disease severity in non-segmental vitiligo. Beni-Suef University Journal of Basic and Applied Sciences, 13(1). https://doi.org/10.1186/s43088-024-00549-y
Guzzo, F., Raucci, C., Zengin, G., et al. (2024). NMR metabolic profiling and biological activities of different extracts from a Turkish herbal tea—Clinopodium nepeta subsp. glandulosum. Biochemical Systematics and Ecology, 117. https://doi.org/10.1016/j.bse.2024.104908
Hassan, A. R., El-Sary, A. Y., El-Sayed, H. S., et al. (2024). Serum irisin level in association with lipid profile and insulin as a marker of metabolic syndrome in vitiligo patients. Fayoum University Medical Journal, 14(2), 70–81. https://doi.org/10.21608/fumj.2024.316431.1387
He, Q., Wang, J., Li, J., et al. (2024). Polyphenol profile and antioxidant, antityrosinase, and anti-melanogenesis activities of ethanol extract of bee pollen. Pharmaceuticals, 17(12). https://doi.org/10.3390/ph17121634
Ismail, S., Normaya, E., Shamsuri, S. S., et al. (2024). Chemometric-assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products. Journal of Supercritical Fluids, 214. https://doi.org/10.1016/j.supflu.2024.106393
Kawakami, A., & Fisher, D. (2017). The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. Laboratory Investigation, 97(6), 649–656. https://doi.org/10.1038/labinvest.2017.9
Kim, D. J., Jung, M. S., Jin, H. U., et al. (2024). Anti-melanogenic effects of umbelliferone: In vitro and clinical studies. Molecules, 29(23). https://doi.org/10.3390/molecules29235571
Kumar, S., Mahajan, S., Kale, D., et al. (2024). Insights into the gut microbiome of vitiligo patients from India. BMC Microbiology, 24(1). https://doi.org/10.1186/s12866-024-03529-5
Lee, S. Y., Baek, N., & Nam, T. G. (2016). Natural, semisynthetic and synthetic tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(1), 1–13. https://doi.org/10.3109/14756366.2015.1004058
Lin, Y.-J., Wu, B.-Q., Chang, C.-C., et al. (2024). Laser-induced optical breakdown as a prior strategy for acquired melanin-increased disorder in dermal layer. Lasers in Medical Science, 39(1). https://doi.org/10.1007/s10103-024-04170-4
Liu, L. Y., Strassner, J. P., Refat, M. A., Harris, J. E., & King, B. A. (2017). Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure. Journal of the American Academy of Dermatology, 77(4), 675–682. https://doi.org/10.1016/j.jaad.2017.05.043
Lu, J., Chua, S. N., Kavanaugh, J. R., et al. (2024). Impact of digital advertising policy on harmful product promotion: Natural language processing analysis of skin-lightening ads. American Journal of Preventive Medicine, 67(6), 811–819. https://doi.org/10.1016/j.amepre.2024.08.006
Mann, T., Gerwat, W., Batzer, J., Eggers, K., Scherner, C., Wenck, H., et al. (2018). Inhibition of human tyrosinase requires molecular motifs distinctively different from mushroom tyrosinase. Journal of Investigative Dermatology, 138(7), 1601–1608. https://doi.org/10.1016/j.jid.2018.01.019
Mikled, P., Chavasiri, W., & Khongkow, M. (2024). Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-80671-0
Olivero-Verbel, J., Quintero-Rincón, P., & Caballero-Gallardo, K. (2024). Aromatic plants as cosmeceuticals: Benefits and applications for skin health. Planta, 260(6). https://doi.org/10.1007/s00425-024-04550-8
Paramita, S., Toruan, V. M. L., Rahma, K., et al. (2024). Stingless bee propolis review as biocosmetics for anti-acne, anti-aging, and skin-whitening. Journal of Apicultural Science, 68(2), 79–106. https://doi.org/10.2478/JAS-2024-0012
Parikh, A. K., & Ogunleye, T. A. (2024). Post-hydroquinone era: Decoding shifting trends in skin-lightening ingredient searches. Journal of Cosmetic Dermatology, 23(12), 4365–4366. https://doi.org/10.1111/jocd.16501
Pillaiyar, T., Manickam, M., & Namasivayam, V. (2017). Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 403–425. https://doi.org/10.1080/14756366.2016.1256882
Saeedi, M., Eslamifar, M., & Khezri, K. (2019). Kojic acid applications in cosmetic and pharmaceutical preparations. Biomedicine & Pharmacotherapy, 110, 582–593. https://doi.org/10.1016/j.biopha.2018.12.006
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The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request.Issue
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Copyright (c) 2026 Lindsay Valerie Andres, Rheajoy A. Enriquez, Deine Westlee R. Gulmatico, Kirk Kenzo M. Tongcua, Jennifer P. Solis

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